Long-term Effect of Recombinant Interferon-Gamma on Moderate and Severe Atopic Dermatitis in Childhood / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 236-242, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-112492
ABSTRACT
PURPOSE:
A number of studies on the treatment of atopic dermatitis have focused on the therapeutic effects of interferon-gamma (IFN-gamma) in patients with severe atopic dermatitis, although therapeutic protocols such as duration and dosage of recombinant IFN-gamma were different among studies. The beneficial effects of IFN-gamma have probably been attributed mainly to its immune modulating effect on the expression of several immunologic mediators although the mechanism of action of IFN-gamma therapy in atopic dermatitis is not clear.OBJECTIVE:
The purpose of the present study was to evaluate the therapeutic effect of recombinant IFN-gamma on moderate to severe atopic dermatitis with changes in immunologic markers such as IgE level and eosionophil cationic protein (ECP).METHODS:
Thirty children with moderate to severe atopic dermatitis were selected for the treatment with recombinant IFN-gamma, and 10 children with atopic dermatitis were recruited for the controls without IFN-gamma treatment. They were followed up every 4 weeks for 3 months after IFN-gamma treatment. We evaluated the SCORAD index and immunologic markers including serum IgE and ECP and total eosinophil and neutrophil counts.RESULTS:
Significant clinical improvement in reduced SCORAD index was observed 12 weeks after treatment with regimen of recombinant IFN-gamma. This clinical outcome was correlated more with changes in eosinophil counts and ECP levels than with those in serum IgE levels.CONCLUSIONS:
The efficacy of recombinant human IFN-gamma therapy for children with moderate to severe atopic dermatitis was maintained without serious side effects for 6 months after final injection of recombinant IFN-gamma. Recombinant IFN-gamma therapy corrected cellular immune deficits, but not humoral immune defects in patients with atopic dermatitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Inmunoglobulina E
/
Biomarcadores
/
Interferón gamma
/
Dermatitis Atópica
/
Eosinófilos
/
Neutrófilos
Tipo de estudio:
Guía de Práctica Clínica
Límite:
Niño
/
Humanos
Idioma:
Coreano
Revista:
Pediatric Allergy and Respiratory Disease
Año:
2008
Tipo del documento:
Artículo
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