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Incidence of Atazanavir-associated Hyperbilirubinemia in Korean HIV Patients: 30 Months Follow-up Results in a Population with Low UDP-glucuronosyltransferase1A1*28 Allele Frequency
Journal of Korean Medical Science ; : 1427-1430, 2010.
Artículo en Inglés | WPRIM | ID: wpr-112651
ABSTRACT
Hyperbilirubinemia is frequently observed in Caucasian HIV patients treated with atazanavir. UDP-glucuronosyltransferase 1A1 polymorphism, UGT1A1*28, which is associated with atazanavir-induced hyperbilirubinemia, is less common in Asians than in Caucasians. However, little is known about the incidence of atazanavir-associated hyperbilirubinemia in Asian populations. Our objective was to investigate the incidence of and tolerability of atazanavir-associated hyperbilirubinemia in Korean HIV patients. The prevalence and cumulative incidence of atazanavir-associated hyperbilirubinemia and UGT1A1*28 allele frequency was investigated in 190 Korean HIV-infected patients treated with atazanavir 400 mg per day. The UGT1A1*28 were examined by direct sequencing of DNA from peripheral whole blood. The UGT1A1*28 allele frequency was 11%. The cumulative incidence of any grade of hyperbilirubinemia was 77%, 89%, 98%, and 100%, at 3, 12, 24, and 30 months, respectively. The cumulative incidence of severe (grade 3-4) hyperbilirubinemia was 21%, 41%, 66%, and 75%, at 3, 12, 24, and 30 months, respectively. However, the point prevalence of severe hyperbilirubinemia did not increase with time and remained around 25%. Our data suggest that atazanavir-associated hyperbilirubinemia is common but transient in a population with low UGT1A1*28 allele frequency.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oligopéptidos / Piridinas / Infecciones por VIH / Incidencia / Estudios de Seguimiento / Regiones Promotoras Genéticas / Glucuronosiltransferasa / Fármacos Anti-VIH / Pueblo Asiatico / Alelos Tipo de estudio: Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Adulto / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oligopéptidos / Piridinas / Infecciones por VIH / Incidencia / Estudios de Seguimiento / Regiones Promotoras Genéticas / Glucuronosiltransferasa / Fármacos Anti-VIH / Pueblo Asiatico / Alelos Tipo de estudio: Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Adulto / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2010 Tipo del documento: Artículo