The Effect of Midazolam on Outward K+ Channel Currents in Rabbit Cerebral Arterial Smooth Muscle Cells / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 67-71, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-113479
ABSTRACT
BACKGROUND:
Midazolam has a direct relaxing effect on vascular smooth muscle, but the mechanisms that this agent produces muscle relaxation are not fully understood. The current study was performed to identify the effects of the midazolam on K+ channels current in rabbit cerebral arterial smooth muscle cells.METHODS:
Whole cell patch-clamp recording technique was used to evaluate the effects of midazolam (0.1 to 100micrometer) on outward K+ channel currents in dispersed rabbit cerebral arterial smooth muscle cells.RESULTS:
Outward K+ currents of rabbit cerebral artery smooth muscle cells were voltage-dependent. Midazolam (10, 100micrometer) tested significantly inhibited outward K+ currents in a dose-dependent manner and half-blocking concentration (IC50) was 15.94micrometer at 60 mV.CONCLUSIONS:
Midazolam inhibit outward K+ currents of rabbit cerebral arterial smooth muscle cells. Further study will be needed to determine the effect of midazolam on calcium channel current because it is unclear if the inhibitory effect of midazolam on outward K+current induces vasoconstriction.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Vasoconstricción
/
Midazolam
/
Canales de Calcio
/
Arterias Cerebrales
/
Miocitos del Músculo Liso
/
Relajación Muscular
/
Músculo Liso
/
Músculo Liso Vascular
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS