The Expression of Vascular Endothelial Growth Factor (VEGF)-C and VEGF-D in Early Gastric Cancer That's Invaded the Submucosa
Journal of the Korean Surgical Society
;
: 48-53, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-113678
ABSTRACT
PURPOSE:
Vascular endothelial growth factor (VEGF)-C and VEGF-D are considered novel growth factors that potentially induce lymphangiogenesis and hyperplasia of lymphatic vessels. The aim of this study was to investigate whether the expressions of VEGF-C and VEGF-D are associated with the clinicophathologic factors, and particularly lymphatic invasion and lymph node metastasis, in early gastric cancers that's invaded the submucosa.METHODS:
Using immunohistochemical staining, we studied the VEGF-C and VEGF-D expressions in the gastric cancer specimens from 83 patients who underwent curative gastrectomy.RESULTS:
The VEGF-C and VEGF-D immunoreactivity was mainly located in the cytoplasm of the tumor cells. There was a positive VEGF-C expression in 27 of 83 cases (32.5%). The VEGF-D positivity rate was lower than the VEGF-C positivity rate. VEGF-D was positive in 20 of 83 cases (24.0%). A VEGF-C positive expression was associated with lymphatic invasion (P=0.018) and lymph node metastasis (P=0.001). However, the expression of VEGF-D had no correlation with any of the clinicopathologic factors, including lymphatic invasion and lymph node metastasis.CONCLUSION:
The VEGF-C expression may have a role in lymph node metastasis of gastric cancer cells. The VEGF-C expression in tumor specimens may be a reliable marker for lymph node metastasis of early gastric cancer that's invaded the submucosa.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Gástricas
/
Citoplasma
/
Péptidos y Proteínas de Señalización Intercelular
/
Vasos Linfáticos
/
Factor A de Crecimiento Endotelial Vascular
/
Factor C de Crecimiento Endotelial Vascular
/
Factor D de Crecimiento Endotelial Vascular
/
Linfangiogénesis
/
Hiperplasia
/
Ganglios Linfáticos
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Surgical Society
Año:
2008
Tipo del documento:
Artículo
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