Clinical Factors Associated with Acquisition of Resistance to Levofloxacin in Stenotrophomonas maltophilia
Yonsei Medical Journal
;
: 987-993, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-113977
ABSTRACT
PURPOSE:
Fluoroquinolones, rapidly gaining prominence in treatment of Stenotrophomonas maltophilia (SMP), are noted for their potency and tolerability. However, SMP may rapidly acquire resistance to fluoroquinolones. We evaluated associations of clinical factors with acquisition of levofloxacin resistance (LFr) in SMP. MATERIALS ANDMETHODS:
Our retrospective cohort study was based on patient data collected between January 2008 and June 2010. Through screening of 1275 patients, we identified 122 patients with data for SMP antibiotic susceptibility testing in > or =3 serial SMP isolates.RESULTS:
We assigned the 122 patients to either the SS group (n=54) in which levofloxacin susceptibility was maintained or the SR group (n=31) in which susceptible SMP acquired resistance. In multivariate regression analysis, exposure to levofloxacin for more than 3 weeks [odds ratio (OR) 15.39, 95% confidential interval (CI) 3.08-76.93, p=0.001] and co-infection or co-colonization with Klebsiella pneumoniae resistant to levofloxacin (OR 4.85, 95% CI 1.16-20.24, p=0.030) were independently associated with LFr acquisition in SMP.CONCLUSION:
Acquisition of LFr during serial sampling of SMP was related to the levofloxacin exposure.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pruebas de Sensibilidad Microbiana
/
Estudios Retrospectivos
/
Infecciones por Bacterias Gramnegativas
/
Stenotrophomonas maltophilia
/
Fluoroquinolonas
/
Levofloxacino
/
Antibacterianos
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2014
Tipo del documento:
Artículo
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