Effect of Parathyroid Hormone on Left Ventricular Hypertrophy in Aged Ovariectomized Rats
Korean Circulation Journal
;
: 953-960, 1998.
Artículo
en Coreano
| WPRIM
| ID: wpr-114163
ABSTRACT
BACKGROUND:
It has been well known that the bone and kidney are the principle organs of parathyroid hormine (PTH) actions. Although patients with primary hyperparathyroidism show a high incidence of LVH and trophic effects of PTH on adult rat ventricular cardiomyocytes were investigated in vitro, effect of PTH on the cardiac tissue in vivo is unknown.METHODS:
We examined the effects of PTH on the cardiomyocyte and interstitial tissue using adult rat heart. Twenty-two female Sprague-Dawley rats were ovariectomized bilaterally at three months old and weighing in 250 - 300 gm in order to exclude the trophic effect of estrogen. We administrated human parathyroid hormone (20 ug subcutaneously 5 times per week) to 12 rats for 4 weeks after raising for 8 weeks (PTH group)the remaining 10 rats received only normal saline (control). We measured left ventricular thickness [IVS+LVPW)/2] and number of cardiomyocytes and interstitial fibrosis on LM (H & E and Masson's trochrome stain) and EM.RESULTS:
1) LV wall thickeness tended to increase in PTH group as compared with control (2.16+/-0.31 vs 1.12+/-0.21 mm, p=0.099). 2) The number of cardiomyocyte in PTH group was significantly less than that of control (61.2+/-13.1 vs 70.5+/-14.9, p=0.003, Magnification x 400). 3) There was no significant change of interstitial fibrosis between PTH group and control.CONCLUSION:
These results shggest that PTH may produce left ventricular hypertrophic effects in aged ovariectomized rat that resulted form hypertrophy of cardiomyocyte without increase of interstitial connetive tissue.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Hormona Paratiroidea
/
Fibrosis
/
Ovariectomía
/
Incidencia
/
Ratas Sprague-Dawley
/
Hipertrofia Ventricular Izquierda
/
Miocitos Cardíacos
/
Hiperparatiroidismo Primario
/
Estrógenos
/
Corazón
Tipo de estudio:
Estudio de incidencia
/
Estudio pronóstico
Límite:
Animales
/
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Korean Circulation Journal
Año:
1998
Tipo del documento:
Artículo
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