HLA-DQB1 allele frequencies and haplotypic associations with DRB1 genes in Koreans / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 535-541, 1999.
Artículo
en Coreano
| WPRIM
| ID: wpr-114669
ABSTRACT
BACKGROUND:
The HLA-DR and DQ genes are known to show in strong linkage disequilibrium. Authors investigated the allele frequencies of HLA-DQB1 genes and HLA-DQB1-DRB1 haplotypic associations in Koreans.METHODS:
HLA-DRB1 and DQB1 typing were performed in 120 unrelated Koreans consisting of normal tissue donors and patients with hematologic diseases using polymerase chain reaction-reverse dot blot hybridization method with INNO-LiPA HLA-DRB and DQB kits (INNOGENETICS, Zwijndrecht, Belgium). Haplotypic associations between DRB1 and DQB1 alleles were calculated according to the formula from Mattiuz et al.RESULTS:
1. Allele frequencies of the five most common DQB1 alleles were DQB1* 0301, 14.4%; 0303, 11.0%; 0302, 9.6%; 0601, 9.2%; 0401, 8.7%. 2. Haplotype frequencies (%) of the ten most common DQB1*-DRB1* haplotypes were 0303-0901, 9.17%; 0401-0405, 8.71%; 0602-1501/03/04, 7.35%; 0501-0101, 7.35%; 0601-0803, 5.98%; 0609-1302, 5.10%; 0503-1405, 4.69%; 0302-0406, 4.26%; 0301-1101/10/12 or 1104, 4.26%; 02-0701, 4.23%. They consisted 61.1% of total haplotypes in this study.CONCLUSIONS:
The results of this study may be useful as basic data of Koreans for anthropology, accurate interpretaion of DRB1 and DQB1 typing and quality control of genotyping.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Control de Calidad
/
Donantes de Tejidos
/
Haplotipos
/
Antígenos HLA-DR
/
Desequilibrio de Ligamiento
/
Alelos
/
Cadenas HLA-DRB1
/
Frecuencia de los Genes
/
Enfermedades Hematológicas
/
Antropología
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Clinical Pathology
Año:
1999
Tipo del documento:
Artículo
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