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The effect of Treponema denticola immunoinhibitory protein on cytokine expression in T cells / 대한치과보존학회지
Journal of Korean Academy of Conservative Dentistry ; : 479-484, 2004.
Artículo en Inglés | WPRIM | ID: wpr-114821
ABSTRACT
Immunoinhibitory protein extracted from sonicated Treponema denticola have been shown to suppress cell cycle progression of human lymphocytes. To study in detail about the effect of this microorganism on the function of lymphocytes, we investigated the levels of Interleukin-2 (IL-2) and Interleukin-4 (IL-4) production by T lymphocytes before and after the addition of 12.5 microg/ml T. denticola sonicated extracts. In this study, levels of IL-2 and IL-4 produced from T cells pretreated with sonicated extracts were evaluated by using the quantitative sandwich enzyme immunoassay technique. In response to phytohemagglutinin (PHA) stimulation, T cell produced increased levels of IL-2 and IL-4. However, the expressions of both cytokines were significantly inhibited when PHA activated-T cells were pre-exposed to sonicated T. denticola extracts (p < 0.05). These findings suggest that the T. denticola sonicated extracts induced-immunosuppression in Th1 and Th2 cell functions could be a part of the pathogenic mechanism of the endodontic failure associated with this microorganism.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Treponema / Linfocitos / Linfocitos T / Ciclo Celular / Citocinas / Técnicas para Inmunoenzimas / Interleucina-4 / Interleucina-2 / Células Th2 / Treponema denticola Límite: Humanos Idioma: Inglés Revista: Journal of Korean Academy of Conservative Dentistry Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Treponema / Linfocitos / Linfocitos T / Ciclo Celular / Citocinas / Técnicas para Inmunoenzimas / Interleucina-4 / Interleucina-2 / Células Th2 / Treponema denticola Límite: Humanos Idioma: Inglés Revista: Journal of Korean Academy of Conservative Dentistry Año: 2004 Tipo del documento: Artículo