Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases
Korean Journal of Pathology
;
: 411-417, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-114870
ABSTRACT
BACKGROUND:
Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1alpha [HNF1alpha]-mutated, beta-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group.METHODS:
We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports.RESULTS:
Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for beta-catenin-mutated HCA. HNF1alpha-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1alpha or beta-catenin genes and no inflammatory protein expression is categorized as unclassified HCA.CONCLUSIONS:
Although the new classification is now generally accepted, validation through follow-up studies is necessary.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteína Amiloide A Sérica
/
Adenoma de Células Hepáticas
/
Beta Catenina
/
Proteínas de Unión a Ácidos Grasos
/
Factor Nuclear 1-alfa del Hepatocito
/
Glutamato-Amoníaco Ligasa
/
Amiloide
/
Hígado
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Korean Journal of Pathology
Año:
2013
Tipo del documento:
Artículo
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