Distribution and characterization of IL-10-secreting cells in lymphoid tissues of PCV2-infected pigs
Journal of Veterinary Science
;
: 177-183, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-115099
ABSTRACT
Distribution and characterization of interlukin-10 (IL-10)-secreting cells in lymphoid tissues of pigs naturally infected with porcine circovirus type 2 (PCV2) were evaluated in accordance with PCV2 antigen detection. After screening a total of 56 pigs showing the symptoms of postweaning multisystemic wasting syndrome (PMWS), 15 pigs were PCV2 positive and 5 pigs, which showed stronger positive signals over multiples tissues were further investigated. This study showed that in PCV2-infected lymphoid tissues, particularly mandibular lymph node, spleen and tonsil, IL-10 expression was mainly localized in T-cell rich areas but rarely in B cell rich areas. IL-10 was highly expressed in bystander cells but rarely in PCV2-infected cells. Elevated IL-10 expression was predominantly associated with T cells, but rarely with B cells or with macrophages. The results of this study provide evidence for the role of IL-10 in chronic PCV2 infection and its relation to PCV2 antigen in affected tissues. Constantly elevated levels of IL-10 lead to immunosuppression in persistent and chronic viral infections. The increased IL-10 expression observed in PCV2 infection in this study suggests that IL-10-mediated immunosuppression may play an important role in the pathogenesis and maintenance of naturally occurring PCV2 infection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Porcinos
/
Inmunohistoquímica
/
Linfocitos T
/
Regulación de la Expresión Génica
/
Interleucina-10
/
Circovirus
/
Infecciones por Circoviridae
/
Síndrome Multisistémico de Emaciación Posdestete Porcino
/
República de Corea
/
Tejido Linfoide
Límite:
Animales
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS