Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin

Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI; Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI

Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI; Seok-Joon LEE; Sang-Tae OH; Gab-Man PARK; Tong-Soo KIM; Jae-Sook RYU; Han-Kyu CHOI.

The Korean Journal of Parasitology ; : 123-126, 2005.

Artículo en Inglés | WPRIM | ID: wpr-115349

ABSTRACT

ABSTRACT

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.

Asunto(s)

Animales; Antimaláricos/química; Artemisininas/química; Cloroquina/farmacología; Resistencia a Medicamentos; Plasmodium falciparum/efectos de los fármacos

Plasmodium falciparum; antimalarial activity; artemisinin; dihydroartemisinin; synthesis; natural product

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasmodium falciparum / Resistencia a Medicamentos / Cloroquina / Artemisininas / Antimaláricos Límite: Animales Idioma: Inglés Revista: The Korean Journal of Parasitology Año: 2005 Tipo del documento: Artículo

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