Prognostic Value of Elevated Cyclooxygenase-2 Expression in Breast Cancer
Journal of the Korean Surgical Society
;
: 377-381, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-115375
ABSTRACT
PURPOSE:
Cyclooxygenase-2 (Cox-2) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and can be induced by various agents such as growth factors and tumor promoters. Cox-2 contributes to carcinogenesis and tumor growth. This study was performed to demonstrate the correlation between elevated expression of Cox-2 and pathologic factors in breast cancer.METHODS:
Cox-2 expression was analyzed immunohistochemically in paraffin-embedded tumor samples from 40 patients with breast cancer. Cox-2 expression was defined as negative or positive. The correlation between Cox-2 expression and pathologic factors (tumor size, axillary lymph node metastasis, TNM stage and histologic grade) was analyzed.RESULTS:
Cox-2 was highly expressed in proportion to tumor size, but the difference was not significant (P>0.05). High Cox-2 expression was observed in the presence of axillary lymph node metastasis and TNM stage III, but was not significant (P>0.05). The Cox-2 expression rate was significantly associated with high histologic grade (I 42.9%, II 50.0%, III 80.0%) (P=0.046).CONCLUSION:
Elevated levels of Cox-2 expression were associated with large tumor size, presence of axillary lymph node metastasis, high TNM stage and high histologic grade, and can therefore be a possible marker for poor prognosis. Due to the small number of cases, we couldn't confirm the statistical significance except in terms of histologic grade. Further prospective studies with a large number of cases are required.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Neoplasias de la Mama
/
Carcinógenos
/
Prostaglandinas
/
Ácido Araquidónico
/
Péptidos y Proteínas de Señalización Intercelular
/
Ciclooxigenasa 2
/
Carcinogénesis
/
Ganglios Linfáticos
/
Metástasis de la Neoplasia
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Surgical Society
Año:
2003
Tipo del documento:
Artículo
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