Correlation between Head Circumference and Cognition in the Elderly by ApoE Genotype / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 254-261, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-115400
ABSTRACT
OBJECTIVES:
The aim of this study is to find out the effect of ApoE genotype on correlation between head circumference and cognition of the elderly in the community.METHODS:
A total of 1,152 subjects (380 men and 772 women) aged 60-91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history and K-MMSE (Korean version-Mini Mental State Examination). We also measured the head circumference and examined ApoE genotype.RESULTS:
On regression analysis, as head circumference becomes smaller, K-MMSE scores decreased adjusted by age, sex, educational level, ApoE epsilon4 allele, current smoking and alcohol drinking status (beta=0.15, p=0.04). Only in the lowest quartile group, presence of ApoE epsilon4 allele reduced K-MMSE scores adjusted by age, sex, educational level, height, current alcohol drinking and smoking status (beta=-1.39, p=0.008).CONCLUSION:
These results suggest that head circumference may have an influence on K-MMSE scores, and presence of ApoE epsilon4 allele may be a medicating factor.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Apolipoproteínas E
/
Humo
/
Consumo de Bebidas Alcohólicas
/
Fumar
/
Encuestas y Cuestionarios
/
Cognición
/
Demencia
/
Alelos
/
Reserva Cognitiva
/
Genotipo
Límite:
Anciano
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Año:
2007
Tipo del documento:
Artículo
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