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Impact on Long-term Adverse Cardiac Events of Troponin T or Creatine Kinase-MB Release after Percutaneous Transluminal Coronary Angioplasty
Korean Circulation Journal ; : 949-957, 2002.
Artículo en Coreano | WPRIM | ID: wpr-115500
ABSTRACT
BACKGROUND AND

OBJECTIVES:

The impact on long-term adverse cardiac events of troponin T (TnT) or creatine kinase-MB (CK-MB) release after percutaneous transluminal coronary angioplasty (PTCA) is not well defined. The purpose of the study is to evaluate the effect of elevated TnT or CK-MB on the late major adverse cardiac events [MACE ; Q wave myocardial infarction (MI), revascularization, or cardiac death]. SUBJECTS AND

METHODS:

Study population were 207 consecutive patients (M F=148 59, mean 60.8+/-9.2 years) who underwent PTCA. Patients with acute MI, unstable angina with abnormal levels of TnT or CK-MB, or newly developed Q MI after PTCA were excluded. Cardiac enzyme levels were measured before and 8, 24 hours after PTCA for CK-MB, and before and 16 hours after PTCA for TnT. Group I (n=181, 87.4%) had normal levels of both after PTCA. Group II (n=26, 12.6%) had abnormal levels of CK-MB (>or=16 U/L) and/or TnT (>or=0.2 ng/mL). 1-year follow-up was available in 201 (97.1%) patients.

RESULTS:

Incidence of non-Q MI after PTCA was 26/207 (12.6%). Major complications such as acute coronary occlusion, side branch occlusion, and major dissection were significantly associated with elevation of TnT or CK-MB after PTCA (p=0.01). However, elevation of CK-MB or TnT was not significantly associated with late MACE by Kaplan-Meier survival curve (p=0.46). During 1-year follow-up, event free rate of group I and II were 76.6% and 69.2%, respectively.

CONCLUSION:

Acute coronary occlusion, side branch occlusion, or major dissection can increase the level of TnT or CK-MB after PTCA. But, elevation of CK-MB or TnT after PTCA dose not significantly influence on late MACE.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Troponina / Trinitrotolueno / Angioplastia Coronaria con Balón / Incidencia / Estudios de Seguimiento / Angioplastia / Troponina T / Creatina / Creatina Quinasa / Oclusión Coronaria Tipo de estudio: Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Korean Circulation Journal Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Troponina / Trinitrotolueno / Angioplastia Coronaria con Balón / Incidencia / Estudios de Seguimiento / Angioplastia / Troponina T / Creatina / Creatina Quinasa / Oclusión Coronaria Tipo de estudio: Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Korean Circulation Journal Año: 2002 Tipo del documento: Artículo