Clinical usefulness of the measurement of serum fructosamine in childhood diabetes mellitus
Annals of Pediatric Endocrinology & Metabolism
;
: 21-26, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-115867
ABSTRACT
PURPOSE:
Glycosylated hemoglobin (HbA1c) is often used as an indicator of glucose control. It usually reflects the average glucose levels over two to three months, and is correlated with the development of long-term diabetic complications. However, it can vary in cases of hemoglobinopathy or an altered red blood cell lifespan. The serum fructosamine levels reflect the mean glucose levels over two to three weeks. This study was designed to determine the clinical usefulness of the combined measurement of serum fructosamine and HbA1c in the management of childhood diabetes mellitus and the correlation between them.METHODS:
Clinical data on 74 Korean children and adolescents with diabetes mellitus who were under management at the Department of Pediatrics of Dankook University Hospital were evaluated. Their fructosamine and HbA1c levels were reviewed based on clinical information, and analyzed using IBM SPSS Statistics ver. 21.RESULTS:
Their HbA1c levels showed a strong correlation with their fructosamine levels (r=0.868, P<0.001). The fructosamine level was useful for the prompt evaluation of the recent therapeutic efficacy after the change in therapeutic modality. It was also profitable in determining the initial therapeutics and for the estimation of the onset of the disease, such as fulminant diabetes.CONCLUSION:
The measurement of both fructosamine and HbA1c was useful in managing childhood diabetes mellitus, especially when there was discrepancy between the clinical information and the HbA1c level.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pediatría
/
Hemoglobina Glucada
/
Fructosamina
/
Complicaciones de la Diabetes
/
Diabetes Mellitus
/
Eritrocitos
/
Glucosa
/
Hemoglobinopatías
Límite:
Adolescente
/
Niño
/
Humanos
Idioma:
Inglés
Revista:
Annals of Pediatric Endocrinology & Metabolism
Año:
2015
Tipo del documento:
Artículo
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