Long-Term Outcome of Amyotrophic Lateral Sclerosis in Korean Subjects
Annals of Rehabilitation Medicine
;
: 1055-1064, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-11662
ABSTRACT
OBJECTIVE:
To report the latest long-term outcome of amyotrophic lateral sclerosis (ALS) and to analyze the predictors of prognosis.METHODS:
Subjects who were diagnosed with ALS between January 2005 and December 2009 at a single institute were followed up until death or up to December 2014. Data regarding age, sex, date of onset, date of diagnosis, presence of bulbar symptoms on onset, date of initiation of non-invasive ventilation (NIV), and the date of tracheostomy were collected. Survival was assessed using Kaplan-Meier curves and multivariate analyses of the risk of death were performed using the Cox proportional hazards model.RESULTS:
Among 212 suspicious subjects, definite ALS was diagnosed in 182 subjects. The survival rate at 3 and 5 years from onset was 61.5% and 40.1%, respectively, and the survival rate at 3 and 5 years post-diagnosis was 49.5% and 24.2%, respectively. Further, 134 patients (134/182, 73.6%) were initiated on NIV, and among them, 90 patients (90/182, 49.5%) underwent tracheostomy. Male gender and onset age of ≥65 years were independent predictors of adverse survival.CONCLUSION:
The analysis of long term survival in ALS showed excellent outcomes considering the overall poor prognosis of this disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Traqueostomía
/
Modelos de Riesgos Proporcionales
/
Análisis Multivariante
/
Tasa de Supervivencia
/
Edad de Inicio
/
Diagnóstico
/
Ventilación no Invasiva
/
Esclerosis Amiotrófica Lateral
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Annals of Rehabilitation Medicine
Año:
2017
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS