Epigallocatechin-3-gallate Regulates Inducible Nitric Oxide Synthase Expression in Human Umbilical Vein Endothelial Cells / 한국실험동물학회지
Laboratory Animal Research
;
: 85-90, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-116724
ABSTRACT
Inducible nitric oxide synthase (iNOS) is a main enzyme producing nitric oxide during inflammation and thus contributes to the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, has multiple beneficial effects for treating cardiovascular disease, but the effect of EGCG on the expression of vascular iNOS remains unknown. In this study, we investigated (i) whether EGCG inhibits the expression of vascular iNOS induced by angiotensin II in human umbilical vein endothelial cells and, if it does inhibit, (ii) mechanisms underlying the inhibition. Angiotensin II increased expression levels of vascular iNOS; EGCG counteracted this effect. EGCG increased the production of reactive oxygen species. Moreover, EGCG did not affect the production of reactive oxygen species induced by angiotensin II. These data suggest a novel mechanism whereby EGCG provides direct vascular benefits for treating inflammatory cardiovascular diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Té
/
Angiotensina II
/
Enfermedades Cardiovasculares
/
Catequina
/
Especies Reactivas de Oxígeno
/
Aterosclerosis
/
Óxido Nítrico Sintasa de Tipo II
/
Células Endoteliales de la Vena Umbilical Humana
/
Inflamación
/
Óxido Nítrico
Límite:
Humanos
Idioma:
Inglés
Revista:
Laboratory Animal Research
Año:
2011
Tipo del documento:
Artículo
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