Treatment of Hemangiopericytoma-Associated Hypoglycemia with Glucocorticoid Therapy / 영남의대학술지
Yeungnam University Journal of Medicine
; : 77-83, 2011.
Article
en Ko
| WPRIM
| ID: wpr-117519
Biblioteca responsable:
WPRO
ABSTRACT
Non-islet cell tumor-induced hypoglycemia (NICTH) is associated with mesenchymal tumor types, including hemangiopericytoma, fibrosarcoma, mesothelioma, and neurofibroma, as well as carcinoma of the liver, adrenal glands, and kidneys. Non-islet cell tumors induce hypoglycemia by overproducing an abnormal form of insulin-like growth factor II (IGF II). Complete removal of the tumor or reduction of the tumor mass is a successful therapeutic strategy in cases of NICTH. However, if the tumor re-grows, curative resection is nearly impossible, and hypoglycemia occurs repeatedly. Glucocorticoids are effective in terms of long-term relief from hypoglycemia through promotion of gluconeogenesis in the liver, tumor suppression, production of 'big'-IGF-II, and correction of the attendant biochemical abnormalities involving the growth hormone (GH)-IGF axis. We found that administration of corticosteroid therapy to a patient suffering from NICTH resulted in improvement of hypoglycemia associated symptoms.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Estrés Psicológico
/
Vértebra Cervical Axis
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Factor II del Crecimiento Similar a la Insulina
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Prednisolona
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Hormona del Crecimiento
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Glándulas Suprarrenales
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Fibrosarcoma
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Glucocorticoides
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Gluconeogénesis
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Hemangiopericitoma
Límite:
Humans
Idioma:
Ko
Revista:
Yeungnam University Journal of Medicine
Año:
2011
Tipo del documento:
Article