Nucleoside Diphosphate Kinase from Microorganisms
Journal of Bacteriology and Virology
;
: 92-98, 2013.
Artículo
en Coreano
| WPRIM
| ID: wpr-117662
ABSTRACT
Nucleoside diphosphate kinase (Ndk) is ubiquitous and highly conserved multifunctional key enzyme in nucleotide metabolism. It generates nucleoside triphosphates (NTPs) by transfer of gamma-phosphates from nucleoside triphosphates such as ATP or GTP to nucleoside diphosphate. The formation of an autophosphorylated enzyme intermediate is involved in that mechanism. The phosphate is usually supplied by ATP and Ndk activity in different subcellular compartments. Ndk may regulate the crucial balance between ATP and GTP or other nucleoside triphosphates. Ndk is playing an important role in bacterial pathogenesis and emerging evidences recognize multiple roles of Ndk in host-microbe interaction. Here, I review some examples of the role of Ndk in intra- and extracellular microorganism.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Adenosina Trifosfato
/
Nucleósido-Difosfato Quinasa
/
Guanosina Trifosfato
Idioma:
Coreano
Revista:
Journal of Bacteriology and Virology
Año:
2013
Tipo del documento:
Artículo
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