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Erythropoietin Antibody-Positive Pure Red Cell Aplasia Diagnosed after Surgical Intervention for Malignant Gastric Ulcer Bleeding / 대한내과학회지
Korean Journal of Medicine ; : 433-437, 2013.
Artículo en Coreano | WPRIM | ID: wpr-117708
ABSTRACT
Rarely, patients on erythropoietin stimulating agent (ESA) therapy develop antibodies that neutralize both ESA and endogenous erythropoietin, resulting in antibody-mediated pure red cell aplasia (PRCA). The sudden development of severe transfusion-dependent anemia requires rapid recognition, the evaluation of PRCA, and prompt intervention after differentiating other causes of anemia, such as iron deficiency, occult bleeding, and infection. Here, we report the case of a 67-year-old male undergoing hemodialysis who presented with the anemia of chronic blood loss from a malignant gastric ulcer. Even after surgical intervention for stomach cancer and increasing the erythropoietin dosage, the anemia was not correctable and required monthly packed red blood cell transfusions. Further evaluation revealed positive erythropoietin antibody, and a bone marrow biopsy showed no red blood cell precursors, supporting the diagnosis of PRCA.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Gástricas / Úlcera Gástrica / Biopsia / Médula Ósea / Eritropoyetina / Diálisis Renal / Aplasia Pura de Células Rojas / Transfusión de Eritrocitos / Eritrocitos / Hemorragia Tipo de estudio: Estudio diagnóstico Límite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Medicine Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Gástricas / Úlcera Gástrica / Biopsia / Médula Ósea / Eritropoyetina / Diálisis Renal / Aplasia Pura de Células Rojas / Transfusión de Eritrocitos / Eritrocitos / Hemorragia Tipo de estudio: Estudio diagnóstico Límite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Medicine Año: 2013 Tipo del documento: Artículo