Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
Toxicological Research
;
: 7-14, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-118070
ABSTRACT
Betaine supplementation has been shown to alleviate altered glucose and lipid metabolism in mice fed a high-fat diet or a high-sucrose diet. We investigated the beneficial effects of betaine in diabetic db/db mice. Alleviation of endoplasmic reticulum (ER) and oxidative stress was also examined in the livers and brains of db/db mice fed a betaine-supplemented diet. Male C57BL/KsJ-db/db mice were fed with or without 1% betaine for 5 wk (referred to as the db/db-betaine group and the db/db group, respectively). Lean non-diabetic db/+ mice were used as the control group. Betaine supplementation significantly alleviated hyperinsulinemia in db/db mice. Betaine reduced hepatic expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha, a major transcription factor involved in gluconeogenesis. Lower serum triglyceride concentrations were also observed in the db/db-betaine group compared to the db/db group. Betaine supplementation induced hepatic peroxisome proliferator-activated receptor alpha and carnitine palmitoyltransferase 1a mRNA levels, and reduced acetyl-CoA carboxylase activity. Mice fed a betaine-supplemented diet had increased total glutathione concentrations and catalase activity, and reduced lipid peroxidation levels in the liver. Furthermore, betaine also reduced ER stress in liver and brain. c-Jun N-terminal kinase activity and tau hyperphosphorylation levels were lower in db/db mice fed a betaine-supplemented diet, compared to db/db mice. Our findings suggest that betaine improves hyperlipidemia and tau hyperphosphorylation in db/db mice with insulin resistance by alleviating ER and oxidative stress.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Acetil-CoA Carboxilasa
/
Factores de Transcripción
/
Betaína
/
Encéfalo
/
Resistencia a la Insulina
/
ARN Mensajero
/
Peroxidación de Lípido
/
Carnitina O-Palmitoiltransferasa
/
Catalasa
/
Estrés Oxidativo
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Toxicological Research
Año:
2013
Tipo del documento:
Artículo
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