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TNF-alpha and IL-12 Secretion in Macrophages in Response to Spores of Bacillus anthracis Sterne
Journal of Bacteriology and Virology ; : 141-150, 2006.
Artículo en Coreano | WPRIM | ID: wpr-118404
ABSTRACT
Baerobic, spore forming, and rod-shaped bacterium. Anthrax spores are introduced into macrophage by phagocytosis and multiply after germination. The anthrax spores infected in macrophage produce lethal toxin eventually caused cell death. In this study, we analyzed apoptosis and cytokine TNF-alpha and IL-12 secretion after the infection of spores of B. anthracis Sterne in the murine macrophage RAW264.7 cells and in the primary human macrophages. In murine macrophage RAW264.7 cells infected by spore of B. anthracis Sterne, the cells were markedly changed in secretion of TNF-alpha (482~6,213 pg/ml) by lethal toxin, and induced apoptosis. In case of RAW264.7 cells infected by formalin-inactivated spores of B. anthracis, the cells were not able to produce lethal toxin, which released lower level concentration of TNF-alpha (7.7~97.2 pg/ml), and rarely induced apoptosis. When primary human macrophage cells infected with spores of B. anthracis Sterne, they secreted TNF-alpha (5~16 pg/ml), and induced apoptosis about 1% of total cells. We presented that inducing apoptosis by spores of B. anthracis Sterne capable of expressing lethal toxin is related with the secretion of TNF-alpha in murine macrophage RAW264.7 cells. These studies revealed that human and murine macrophages has affected differently by anthrax lethal toxin produced by spores of B. anthracis Sterne.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fagocitosis / Esporas / Bacillus / Bacillus anthracis / Factor de Necrosis Tumoral alfa / Muerte Celular / Apoptosis / Interleucina-12 / Germinación / Macrófagos Límite: Humanos Idioma: Coreano Revista: Journal of Bacteriology and Virology Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fagocitosis / Esporas / Bacillus / Bacillus anthracis / Factor de Necrosis Tumoral alfa / Muerte Celular / Apoptosis / Interleucina-12 / Germinación / Macrófagos Límite: Humanos Idioma: Coreano Revista: Journal of Bacteriology and Virology Año: 2006 Tipo del documento: Artículo