Identification of HLA-B*5001 in Korean Population / 대한소아혈액종양학회지
Korean Journal of Pediatric Hematology-Oncology
;
: 323-330, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-118583
ABSTRACT
PURPOSE:
HLA (human leukocyte antigen)-class I genes are highly polymorphic, play many roles in organ and bone marrow transplantation. HLA-B is the most polymorphic class I locus with 414 alleles. HLA-class I typing, which is based on serologic method, has been used until recently. The development of molecular biological techniques make it possible to define the genotypes of HLA genes.METHODS:
Analyses of HLA-B genotyping on 1,000 UCB (Umbilical Cord Blood) samples which were considered to be HLA-B homozygote or blank were performed by ARMS-PCR (Amplification Refractory Mutation System-PCR) method and direct sequencing.RESULTS:
We could identify HLA-B*5001 which was known to be absent in Koreans.CONCLUSION:
It is strongly suggested that HLA-B homozygote should be confirmed to the DNA level especially in cases of donor selection for the unrelated bone marrow transplantation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ADN
/
Antígenos HLA-B
/
Trasplante de Médula Ósea
/
Selección de Donante
/
Alelos
/
Sangre Fetal
/
Genotipo
/
Homocigoto
/
Leucocitos
Tipo de estudio:
Estudio diagnóstico
Idioma:
Coreano
Revista:
Korean Journal of Pediatric Hematology-Oncology
Año:
2001
Tipo del documento:
Artículo
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