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The Clinical Outcome of Protocol R-11 Chemotherapy in Patients with Late Relapse of Childhood Acute Lymphoblastic Leukemia / 대한소아혈액종양학회지
Korean Journal of Pediatric Hematology-Oncology ; : 197-205, 2001.
Artículo en Coreano | WPRIM | ID: wpr-118598
ABSTRACT

PURPOSE:

This study is to see chemotherapeutic results followed by Rotational Combination Chemotherapy (R-11 protocol) treatment for the patients with late relapse of childhood ALL six months after the completion of chemotherapy.

METHODS:

The subjects of study were the 13 children who had been diagnosed as ALL at the Severance Hospital and the Wonju Christian Hospital and completed the chemotherapy. They, however, diagnosed a late relapse of ALL between December, 1996 and December, 2001. After that, they were given an chemotherapy with R-11 protocol.

RESULTS:

The average age of the 13 patients was 11.8 ( 2.8) years old at relapse. They showed the complete remission (8 patients, 61%), partial remission (4, 31%), and induction failure (1, 8%). The total remission ratio was 92%. Four year Event Free Survival (EFS) after the second remission was 61.5%. They also showed acute toxicity during remission induction with severe than grade III according to the WHO criteria. The leukopenia and thrombocytopenia (hematologic toxicity) were seen at 11 cases (84%) and 9 cases (69%) respectively, and hepatotoxicity (non-hematologic toxicity) was shown at 6 cases (46%). There are also chronic toxicity, one case developed leukomalacia, and 6 cases did various symptoms of infections.

CONCLUSION:

There is no optimal chemotherapeutic protocol for late relapse of childhood ALL, and the treatment with R-11 protocol is worth a trial.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recurrencia / Trombocitopenia / Inducción de Remisión / Supervivencia sin Enfermedad / Quimioterapia / Quimioterapia Combinada / Leucemia-Linfoma Linfoblástico de Células Precursoras / Leucopenia Tipo de estudio: Guía de Práctica Clínica Límite: Niño / Humanos Idioma: Coreano Revista: Korean Journal of Pediatric Hematology-Oncology Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recurrencia / Trombocitopenia / Inducción de Remisión / Supervivencia sin Enfermedad / Quimioterapia / Quimioterapia Combinada / Leucemia-Linfoma Linfoblástico de Células Precursoras / Leucopenia Tipo de estudio: Guía de Práctica Clínica Límite: Niño / Humanos Idioma: Coreano Revista: Korean Journal of Pediatric Hematology-Oncology Año: 2001 Tipo del documento: Artículo