Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast Cancer Cell-line / 한국유방암학회지
Journal of Korean Breast Cancer Society
; : 277-282, 2003.
Article
en Ko
| WPRIM
| ID: wpr-118846
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: The isoflavones in soy are likely to contribute to the historically low incidence of breast cancer among Asian women that consume traditional diets. A possible role of isoflavones in controlling the expression of cyclooxygenase-2 (Cox-2) has not previously been explored. In this study, the ability of the isoflavone, genistein, to regulate the expression of Cox-2 in breast cancer cells was evaluated. METHODS: The effects of genistein and NS-398, a Cox-2 inhibitor, were examined on the expression of Cox-2 at the mRNA level using the MDA-MB 231, and MCF-7 breast cancer cell-lines. RESULTS: In the MCF-7 cells, the Cox-2 mRNA could not be detected using RT-PCR. In the MDA-MB-231 cells, NS-398 and genistein were found to inhibit the Cox-2 mRNA expressions by 50 and 35~40%, respectively. CONCLUSION: These studies suggest that dietary isoflavonoids may contribute to the prevention or inhibition of breast cancer by inhibiting the Cox-2 expression.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Mama
/
Neoplasias de la Mama
/
ARN Mensajero
/
Incidencia
/
Genisteína
/
Pueblo Asiatico
/
Dieta
/
Ciclooxigenasa 2
/
Células MCF-7
/
Isoflavonas
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
Ko
Revista:
Journal of Korean Breast Cancer Society
Año:
2003
Tipo del documento:
Article