The clinical significance of Interleukin-6 mRNA expression in cervical intraepithelial neoplasia and cervical cancer / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 659-665, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-118923
ABSTRACT
OBJECTIVES:
Interleukin-6 is a pleiotrophic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied IL-6 mRNA expression in cervical cancer, CIN and normal cervix. And we questioned whether its expression is related to cervical carcinogenesis and other prognostic factors.METHODS:
The normal cervical and cervical cancer tissues were taken from healthy women (n=16), and the patients with CIN (n=36) and cervical cancer (n=36). The IL-6 mRNA expression was examined by quantitative competitive PCR after polymerase chain reaction amplification of reverse transcriptase copies of RNA transcripts (RT-PCR).RESULTS:
There was no statistically different among cervical cancer, CIN and normal cervix (p>0.05). The IL-6 mRNA expression was not different according to the grades of CIN. Its expression was not correlated with the stage of cervical cancer, size of tumor, and histopathologic type (p>0.05).CONCLUSION:
These results suggested that IL-6 mRNA expression might not be associated with the cervical carcinogenesis and prognosis of cervical cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
ARN
/
ARN Mensajero
/
Queratinocitos
/
Displasia del Cuello del Útero
/
Neoplasias del Cuello Uterino
/
Cuello del Útero
/
Reacción en Cadena de la Polimerasa
/
Interleucina-6
/
ADN Polimerasa Dirigida por ARN
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2002
Tipo del documento:
Artículo
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