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Expression of Prostatic Carcinoma Oncogene PTI - 1 in Prostatic Carcinoma , Prostatic Intraepithelial Neoplasia and Benign Prostatic Hyperplasia Using in situ PCR / 대한암학회지
Journal of the Korean Cancer Association ; : 136-147, 2000.
Artículo en Coreano | WPRIM | ID: wpr-11908
ABSTRACT

PURPOSE:

Prostatic tumor induced gene-1 (PTI-1) is a mutated human EF-la and putative prostatic carcinoma tumor-inducing oncogene, that is differently expressed in prostatic cancer and benign prostatic hyperplasia. And, it is more sensitive marker than prostate- specific antigen (PSA) for detecting human prostate cancer in the bloodstream. This study invastigated the expression of PTI-1 in paraffin embedded tissue of prostatic carcinoma, prostatic intraepithelial neoplasia, and benign prostatic hyperplasia using in situ PCR. MATERIALS AND

METHODS:

we evaluated expression of PTI-1 in prostatic carcinoma with prostatic intraepithelial neoplasia (PIN) of 32 cases, benign hyperplasia of 20 cases, high grade transitional cell carcinoma of 10 cases and colon cancer of 10 cases for control group. Also, the immunohistochemical staining for PSA was performed to comparison with clinical value of PSA.

RESULTS:

The serum level of PSA was closely related to stage and Gleason score (p < 0.05). However, the results of immunohistochemical stains were variable to stage and Gleason score. PTI-1 using in situ PCR expressed in 50% of prostatic carcinoma, 41% of prostatic intraepithelial neoplasia, 10% of benign hyperplasia and colon cancer (p < 0.05). No expression is observed in transitional cell carcinoma. In prostatic carcinoma, PTI-1 expressed in 43.8% (7/16) of stage II, 50.0% (5/10) of stage III, and 66.7% (4/6) of stage IV (p<0.05). In PIN, expression of PTI-1 was similar to prostatic carcinoma (p<0.05).

CONCLUSION:

PTI-1 represented a relatively sensitive marker for prostatic carcinoma and PIN, indicator of prostatic carcinoma progression.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oncogenes / Parafina / Hiperplasia Prostática / Neoplasias de la Próstata / Carcinoma de Células Transicionales / Reacción en Cadena de la Polimerasa / Neoplasias del Colon / Neoplasia Intraepitelial Prostática / Colorantes / Clasificación del Tumor Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Cancer Association Año: 2000 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oncogenes / Parafina / Hiperplasia Prostática / Neoplasias de la Próstata / Carcinoma de Células Transicionales / Reacción en Cadena de la Polimerasa / Neoplasias del Colon / Neoplasia Intraepitelial Prostática / Colorantes / Clasificación del Tumor Límite: Humanos Idioma: Coreano Revista: Journal of the Korean Cancer Association Año: 2000 Tipo del documento: Artículo