Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia
Annals of Laboratory Medicine
;
: 8-13, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-119346
ABSTRACT
Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. Unlike that in Caucasians, thrombophilia that is common in the Japanese and Chinese involve dysfunction of the activated protein C (APC) anticoagulant system caused by abnormal protein S and protein C molecules. Approximately 50% of Japanese and Chinese individuals who develop venous thrombosis have reduced activities of protein S. The abnormal sites causing the protein S molecule abnormalities are distributed throughout the protein S gene, PROS1. One of the most common abnormalities is protein S Tokushima (K155E), which accounts for about 30% of the protein S molecule abnormalities in the Japanese. Whether APC dysfunction occurs in other Asian countries is an important aspect of mapping thrombophilia among Asians. International surveys using an accurate assay system are needed to determine this.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Coagulación Sanguínea
/
Proteína C
/
Proteínas Sanguíneas
/
Proteína S
/
Trombofilia
/
Trombosis de la Vena
/
Pueblo Asiatico
Límite:
Humanos
Idioma:
Inglés
Revista:
Annals of Laboratory Medicine
Año:
2013
Tipo del documento:
Artículo
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