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Magnetic resonance imaging following treatment of advanced hepatocellular carcinoma with sorafenib
Clinical and Molecular Hepatology ; : 218-222, 2014.
Artículo en Inglés | WPRIM | ID: wpr-119480
ABSTRACT
Hepatocellular carcinomas are highly vascular tumors, showing progressive hypervascularity by the process of neoangiogenesis. Tumor angiogenesis is critical for tumor growth as well as metastatic spread therefore, imaging and quantification of tumor neo-angiogenesis is essential for monitoring response to targeted therapies and predicting disease progression. Sorafenib is a molecular targeting agent used for treating hypervascular tumors. This drug is now the standard of care in treatment of patients with advanced hepatocellular carcinoma. Due to its anti-angiogenic and anti-proliferative actions, imaging findings following treatment with Sorafenib are quite distinct when compared to conventional chemotherapeutic agents. Liver MRI is a widely adopted imaging modality for assessing treatment response in hepatocellular carcinoma and imaging features may reflect pathophysiological changes within the tumor. In this mini-review, we will discuss MRI findings after Sorafenib treatment in hepatocellular carcinoma and review the feasibility of MRI as an early biomarker in differentiating responders from non-responders after treatment with molecular targeting agents.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Compuestos de Fenilurea / Imagen por Resonancia Magnética / Tomografía Computarizada por Rayos X / Niacinamida / Carcinoma Hepatocelular / Neoplasias Hepáticas / Antineoplásicos Tipo de estudio: Estudio pronóstico Límite: Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Clinical and Molecular Hepatology Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Compuestos de Fenilurea / Imagen por Resonancia Magnética / Tomografía Computarizada por Rayos X / Niacinamida / Carcinoma Hepatocelular / Neoplasias Hepáticas / Antineoplásicos Tipo de estudio: Estudio pronóstico Límite: Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Clinical and Molecular Hepatology Año: 2014 Tipo del documento: Artículo