Glycopeptide Antibiotics: Structure and Mechanisms of Action
Journal of Bacteriology and Virology
;
: 67-78, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-119552
ABSTRACT
Glycopeptides of the clinically important antibiotic drugs are glycosylated cyclic or polycyclic nonribosomal peptides. Glycopeptides such as vancomycin and teicoplanin are often used for the treatment of gram-positive bacteria in patients. The increased incidence of drug resistance and inadequacy of these therapeutics against gram-positive bacterial infections would be the formation and clinical development of more variable second generation of glycopeptide antibiotics semisynthetic lipoglycopeptide analogs such as telavancin, dalbavancin, and oritavancin with improved activity and better pharmacokinetic properties. In this review, we describe the development of and bacterial resistance to vancomycin, teicoplanin, and semisynthetic glycopeptides (teicoplanin, dalbavancin, and oritavancin). The clinical influence of resistance to glycopeptides, particularly vancomycin, are also discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Péptidos
/
Resistencia a Medicamentos
/
Glicopéptidos
/
Vancomicina
/
Incidencia
/
Infecciones por Bacterias Grampositivas
/
Teicoplanina
/
Bacterias Grampositivas
/
Antibacterianos
Tipo de estudio:
Estudio de incidencia
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Bacteriology and Virology
Año:
2015
Tipo del documento:
Artículo
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