Factors Affecting the First 3-year Quality of Graft Function after Live Donor Kidney Transplantation
Journal of the Korean Surgical Society
;
: 789-801, 2000.
Artículo
en Coreano
| WPRIM
| ID: wpr-119595
ABSTRACT
PURPOSE:
We designed this study to identify the risk factors affecting the quality of graft after live donor kidney transplantation.METHODS:
The study cohort included 259 adult patients who had been followed up for an average of 37 months after transplantation. Cyclosporine (CsA) and steroids were used as main immunosuppressive agents. Seven variables [HLA match, numbers of acute rejection (AR) within post-transplant 1 year, blood type compatibility, use of anti-lymphocyte antibody, age of donor (DA), age of recipient, and the donor kidney weight to recipient body weight ratio (KW/BW)] were examined by multiple regression analysis during the first 3 years. Serum creatinine (Scr), creatinine clearance rate (Ccr) and the 24 hours urinary excretion of protein (24 UP) were used as parameters.RESULTS:
AR, DA, or KW/BW independently affected the quality of graft function. Scr, Ccr, or 24 UP at post-transplant 1 year was strongly correlated with AR (p<0.0001, p=0.002, or p=0.002, respectively). However, Scr, Ccr, or 24 UP at post-transplant 3 years was strongly affected by KW/BW (p<0.0001, p<0.0001, or p=0.008, respectively) or DA (p<0.0001, p=0.001, or p=0.039, respectively).CONCLUSION:
Non-immunologic factors independently affected the graft function through the study periods. The impact of non-immunologic factors on the function of the graft increased year by year. During renal allocation, KW/BW and DA should be included as reference indices to improve the long-term graft function.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Esteroides
/
Donantes de Tejidos
/
Peso Corporal
/
Factores de Riesgo
/
Estudios de Cohortes
/
Trasplante de Riñón
/
Ciclosporina
/
Trasplantes
/
Creatinina
/
Inmunosupresores
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Surgical Society
Año:
2000
Tipo del documento:
Artículo
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