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Comparison of Ertapenem and Ceftriaxone Therapy for Acute Pyelonephritis and Other Complicated Urinary Tract Infections in Korean Adults: A Randomized, Double-Blind, Multicenter Trial
Journal of Korean Medical Science ; : 476-483, 2012.
Artículo en Inglés | WPRIM | ID: wpr-119908
ABSTRACT
The efficacy and safety of ertapenem, 1 g once daily, were compared with that of ceftriaxone, 2 g once daily, for the treatment of adults with acute pyelonephritis (APN) and complicated urinary tract infections (cUTIs) in a prospective, multicenter, double-blinded, randomized study. After > or = 3 days of parenteral study therapy, patients could be switched to an oral agent. Of 271 patients who were initially stratified by APN (n = 210) or other cUTIs (n = 61), 66 (48.9%) in the ertapenem group and 71 (52.2%) in the ceftriaxone group were microbiologically evaluable. The mean duration of parenteral and total therapy, respectively, was 5.6 and 13.8 days for ertapenem and 5.8 and 13.8 days for ceftriaxone. The most common pathogen was Escherichia coli. At the primary efficacy endpoint 5-9 days after treatment, 58 (87.9%) patients in the ertapenem group and 63 (88.7%) in the ceftriaxone had a favorable microbiological response. When compared by stratum and severity, the outcomes in the two groups were equivalent. The frequency and severity of drug-related adverse events were generally similar in both treatment groups. The results indicate that ertapenem is highly effective and safe for the treatment of APN and cUTIs.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pielonefritis / Infecciones Urinarias / Ceftriaxona / Oportunidad Relativa / Método Doble Ciego / Enfermedad Aguda / Factores de Riesgo / Beta-Lactamas / República de Corea / Antibacterianos Tipo de estudio: Ensayo Clínico Controlado / Estudio de etiología / Factores de riesgo Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pielonefritis / Infecciones Urinarias / Ceftriaxona / Oportunidad Relativa / Método Doble Ciego / Enfermedad Aguda / Factores de Riesgo / Beta-Lactamas / República de Corea / Antibacterianos Tipo de estudio: Ensayo Clínico Controlado / Estudio de etiología / Factores de riesgo Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2012 Tipo del documento: Artículo