The Dose-related Effects of Alfentanil on Respiratory and Cardiovascular Function / 대한마취과학회지

ABSTRACT

To evaluate the effects of a1fentanil doses on cardiovascular and respiratory function, changes in mean arterial pressure (MAP), heart rate (HR), respiratory rate(RR) and PaCO2 induced by alfentanil (5 and 10 ug/kg) after intravenous administration over 10 s were measured in 20 young adult male patients (ASA physical status 1) who were scheduled for lower extremity operations under spinal anesthesia. After fixation of spinal anesthesia level and stabilization of vital signs, control measurements were done. MAP and HR were measured at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30 min and, RR and PaCO2 were measured at 5, 10, 15, 20, 30 min after alfentanil administration. While there were no significant changes in MAP or HR in either of the two groups after alfentanil administration, RR and PaCO2 showed significant changes and returned to control values by 10 and 20 min, respectively, with low doses of alfentanil and by 30 and 30 min, respectively, with high doses of alfentanil. These results suggest that 5 or 10 ug/kg of alfentanil has no influence on cardiovascular function but, as the administered dose is increased, RR and minute ventilation decrease more profoundly and recovery is delayed.