Induction of antibody and interferon-gamma production in mice immunized with virus-like particles of swine hepatitis E virus
Journal of Veterinary Science
;
: 575-578, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-120175
ABSTRACT
Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-gamma than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-gamma production in immunized mice.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Porcinos
/
Enfermedades de los Porcinos
/
Vacunas contra Hepatitis Viral
/
Inmunización
/
Interferón gamma
/
Virus de la Hepatitis E
/
Hepatitis E
/
Proteínas de la Cápside
/
Vacunas de Partículas Similares a Virus
/
Ratones Endogámicos BALB C
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2014
Tipo del documento:
Artículo
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