Aspirin Reduces Acute Lung Injury in Rats Subjected to Severe Hemorrhage / 결핵
Tuberculosis and Respiratory Diseases
;
: 522-531, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-120391
ABSTRACT
BACKGROUND:
Hemorrhagic shock and trauma are two of the most common causes of acute lung injury. The activation of cyclooxygenase is one of the important causes of acute lung injury. This study investigated the effect of aspirin, a well-known cyclooxygenase inhibitor, on severe hemorrhage-induced acute lung injury in rats.METHODS:
The hemorrhagic shock was induced by withdrawing blood; 20ml/kg of B.W., through the femoral artery in 5 min. The mean arterial pressure was recorded through the femoral artery on a polygraph.RESULTS:
In the present investigation, the lung tissue myeloperoxidase activity, protein contents and leukocyte counts, in bronchoalveolar lavage fluid, increased significantly 2 and 24 h after the hemorrhage induction. Although the decreased mean arterial pressure spontaneously recovered, acute lung injury occurred after severe hemorrhage. These changes were effectively prevented by a single intravenous injection of aspirin (10 mg/kg of B.W.) 30 min before the hemorrhage.CONCLUSION:
These results suggest that severe hemorrhage-induced acute lung injury is mediated, in part, by the activation of cyclooxygenase. Furthermore, pretreatment of aspirin in acute lung injury-prone patients, or prophylactic treatment of aspirin to the patients with precipitating conditions, could be helpful in the prevention of acute lung injury.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Choque Hemorrágico
/
Líquido del Lavado Bronquioalveolar
/
Aspirina
/
Prostaglandina-Endoperóxido Sintasas
/
Peroxidasa
/
Lesión Pulmonar Aguda
/
Arteria Femoral
/
Presión Arterial
/
Hemorragia
/
Inyecciones Intravenosas
Límite:
Animales
/
Humanos
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Año:
2003
Tipo del documento:
Artículo
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