Spindle Cell Squamous Cell Carcinoma of the Lower Extremities; Case Report / 대한피부과학회지

ABSTRACT

Spindle cell squamous cell carcinoma (SCSCC) is relatively uncommon, but may be encountered. It poses a challenge in the differential diagnosis in that it includes other spindle cell neoplasms. An 81-year-old female with a raised and exophytic plaque with central ulceration surrounding erythematous patches of the left lower extremities, which was gradually and very slowly increasing in size was admitted to our hospital. After resection, conventional histopathological investigation showed spindle-shaped cells showing hyperchromatic nuclei and mitosis, infiltrating the dermis in a storiform pattern. Immunohistochemical analysis revealed that SCSCC was positive for cytokeratins (AE1/AE3, CAM 5.2, 34betaE12) and mesenchymal markers (vimentin, SMA), but was negative for p63, CD34, CD68, melan A and S-100.