Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice / 대한수의학회지
Korean Journal of Veterinary Research
;
: 57-60, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-121221
ABSTRACT
To investigate kinetics of free 177Lu and 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of 5 microCi/mouse or 15 mg/kg body weight, respectively. Free 177Lu radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. 177Lu-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Radiactividad
/
Bazo
/
Suspensiones
/
Venas
/
Peso Corporal
/
Encéfalo
/
Cinética
/
Epidídimo
/
Nanopartículas
/
Hierro
Límite:
Animales
Idioma:
Inglés
Revista:
Korean Journal of Veterinary Research
Año:
2015
Tipo del documento:
Artículo
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