Effect of Ultra-marathon (308 km) Race on Bone Metabolism and Cartilage Damage Biomarkers
Annals of Rehabilitation Medicine
;
: 80-87, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-122701
ABSTRACT
OBJECTIVE:
To evaluate the potential effects of a 308-km ultra-marathon on bone and cartilage biomarkers.METHOD:
Venous blood samples were collected at pre-race, 100 km, 200 km, and 308 km checkpoints. The following markers of cartilage damage and bone metabolism were studied osteocalcin (OC), osteoprotegerin (OPG), and calcium, phosphorous, and cartilage oligomeric matrix protein (COMP).RESULTS:
Blood samples were taken from 20 male runners at four different checkpoints. Serum COMP was increased by 194.1% (130.7% at 100 km and 160.4% at 200 km). Serum OPG was significantly increased by 158.57% at 100 km and 114.1% at 200 km compared to the pre-race measures. OC was transiently suppressed at 200 km. Serum calcium and phosphorous concentrations decreased compared to the pre-race measures.CONCLUSION:
This study showed that the 308-km ultra-marathon induced several changes, including transient uncoupling of bone metabolism, increased bone resorption, suppressed bone formation, and bone turnover and had a major impact on cartilage structure.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteogénesis
/
Resorción Ósea
/
Glicoproteínas
/
Biomarcadores
/
Cartílago
/
Osteocalcina
/
Calcio
/
Proteínas de la Matriz Extracelular
/
Grupos Raciales
/
Osteoprotegerina
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Annals of Rehabilitation Medicine
Año:
2012
Tipo del documento:
Artículo
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