A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
Journal of Korean Medical Science
;
: 750-752, 2004.
Artículo
en Inglés
| WPRIM
| ID: wpr-123117
ABSTRACT
We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B. This case suggests the clinical usefulness of pharmacogenetic testing in individualized dosage adjustments of NT.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Citocromo P-450 CYP2D6
/
Depresión
/
Genotipo
/
Antidepresivos Tricíclicos
/
Nortriptilina
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2004
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS