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Relationship between the Severity of Diversion Colitis and the Composition of Colonic Bacteria: A Prospective Study
Gut and Liver ; : 170-176, 2014.
Artículo en Inglés | WPRIM | ID: wpr-123194
ABSTRACT
BACKGROUND/

AIMS:

Diversion colitis is the inflammation of the excluded segment of the colon in patients undergoing ostomy. It has been suggested that a change in colonic flora may lead to colitis; however, direct evidence for this disease progression is lacking. The aim of this study was to evaluate the relationship between the severity of diversion colitis and the composition of colonic bacteria.

METHODS:

We used culture methods and polymerase chain reaction to analyze the colonic microflora of patients who underwent rectal cancer resection with or without diversion ileostomy. In the diversion group, we also evaluated the severity of colonoscopic and pathologic colitis before reversal.

RESULTS:

This study enrolled 48 patients 26 in the diversion group and 22 in the control group. Significant differences were observed between the two groups in the levels of Staphylococcus (p=0.038), Enterococcus (p<0.001), Klebsiella (p<0.001), Pseudomonas (p=0.015), Lactobacillus (p=0.038), presence of anaerobes (p=0.019), and Bifidobacterium (p<0.001). A significant correlation between the severity of colitis and bacterial composition was only observed for Bifidobacterium (p=0.005, correlation coefficient=-0.531).

CONCLUSIONS:

The colonic microflora differed significantly between the diversion and control groups. Bifidobacterium was negatively correlated with the severity of diversion colitis.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias del Recto / Ileostomía / Estudios de Casos y Controles / Reacción en Cadena de la Polimerasa / Estudios Prospectivos / Colitis / Colon / Reservoritis / Bacterias Gramnegativas / Bacterias Grampositivas Tipo de estudio: Estudio observacional Límite: Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Inglés Revista: Gut and Liver Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias del Recto / Ileostomía / Estudios de Casos y Controles / Reacción en Cadena de la Polimerasa / Estudios Prospectivos / Colitis / Colon / Reservoritis / Bacterias Gramnegativas / Bacterias Grampositivas Tipo de estudio: Estudio observacional Límite: Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Inglés Revista: Gut and Liver Año: 2014 Tipo del documento: Artículo