Two Cases of Multidrug-Resistant Human Immunodeficiency Virus Infection Treated with Atazanavir and Lopinavir/Ritonavir Combination Therapy
Journal of Korean Medical Science
; : 737-739, 2008.
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| ID: wpr-123473
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ABSTRACT
The combination of atazanavir (ATV) and lopinavir/ritonavir (LPV/RTV) with nucleoside reverse transcriptase inhibitors (NRTI) has been used as a salvage regimen for human immunodeficiency virus (HIV)-positive patients. In this paper, we discuss two cases of HIV-positive patients who had long histories of virological failure following a heavy treatment of antiretroviral drugs, but then achieved virological suppression with double-boosted protease inhibitor (PI) regimens. In patients with multiple genotypic resistance to PIs and NRTIs, virological suppression can be achieved with a combination of ATV plus LPV/RTV with an NRTI backbone. The two cases in this report suggest that a combination of ATV plus LPV/RTV could be a useful salvage regimen for the subset of HIV-positive patients with limited treatment options.
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Asunto principal:
Oligopéptidos
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Piridinas
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Pirimidinonas
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Infecciones por VIH
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Inhibidores de la Proteasa del VIH
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Ritonavir
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Farmacorresistencia Viral Múltiple
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Quimioterapia Combinada
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2008
Tipo del documento:
Article