Risk Factors for Recurrence After Surgical Treatment of a Malignant Phyllodes Tumor of the Breast / 한국유방암학회지
Journal of Breast Cancer
;
: 248-253, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-123867
ABSTRACT
PURPOSE:
Malignant phyllodes tumors are rare breast tumors. Information on the prognosis and optimal treatment of these lesions is not yet sufficient. The aim of this study was to determine parameters that predict the recurrence of malignant phyllodes tumors of the breast.METHODS:
Retrospectively, we reviewed the medical records and pathological slides of 23 patients with malignant phyllodes tumors that had undergone surgical treatment from 1988 to 2006. The age of the patients, tumor size, type of surgery, resection margin, adjuvant therapy and pathological characteristics of the tumors such as stromal hypercellularity, cellular phleomorphism, mitosis, margins, and stromal pattern were examined.RESULTS:
The mean age of the patients was 41 yr. The tumor size ranged from 1 cm to 25 cm, with a median of 7.42 cm. The median follow-up time was 29.0 months. Recurrence was observed in 6 patients (26.1%) and the 5-yr disease free survival was 48.9%. Risk factors for recurrence of a malignant phyllodes tumor were a mitotic index greater than 10 per high-powered field (p=0.0242) and an invasive margin (p=0.0437).CONCLUSION:
Frequent mitosis and an invasive margin were the principal determinants of recurrence. Patients with poor prognostic components should be treated more aggressively and the patients need more close follow-up.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Recurrencia
/
Mama
/
Neoplasias de la Mama
/
Registros Médicos
/
Estudios Retrospectivos
/
Factores de Riesgo
/
Estudios de Seguimiento
/
Tumor Filoide
/
Supervivencia sin Enfermedad
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of Breast Cancer
Año:
2007
Tipo del documento:
Artículo
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