Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism
Diabetes & Metabolism Journal
;
: 327-336, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-123921
ABSTRACT
Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. However, relying on UCP1-based thermogenesis alone may not be sufficient to control obesity in humans. On the other hand, skeletal muscle is the largest organ and a major contributor to basal metabolic rate and increasing energy expenditure in muscle through nonshivering thermogenic mechanisms, which can substantially affect whole body metabolism and weight gain. In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Metabolismo Basal
/
Tejido Adiposo Pardo
/
Ingestión de Energía
/
Aumento de Peso
/
Músculo Esquelético
/
Termogénesis
/
Diabetes Mellitus
/
Metabolismo Energético
/
Tejido Adiposo Blanco
/
ATPasas Transportadoras de Calcio del Retículo Sarcoplásmico
Límite:
Humanos
Idioma:
Inglés
Revista:
Diabetes & Metabolism Journal
Año:
2017
Tipo del documento:
Artículo
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