Chronic Opisthorchis viverrini Infection and Associated Hepatobiliary Disease Is Associated with Iron Loaded M2-like Macrophages
The Korean Journal of Parasitology
;
: 695-699, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-124051
ABSTRACT
Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Opistorquiasis
/
Opisthorchis
/
Inmunohistoquímica
/
Mesocricetus
/
Perfilación de la Expresión Génica
/
Histocitoquímica
/
Hierro
/
Cirrosis Hepática
/
Macrófagos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
The Korean Journal of Parasitology
Año:
2014
Tipo del documento:
Artículo
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