Participation of IL-1β in temporomandibular nociception in rats with CFA-induced inflammation
International Journal of Oral Biology
;
: 125-131, 2016.
Artículo
en Coreano
| WPRIM
| ID: wpr-124490
ABSTRACT
The aim of the present study was to develop an animal model for evaluation of temporomandibular (TMJ) nociception under TMJ inflammation. We also investigated the participation of IL-1β in inflammation-induced TMJ nociception. Experiments were carried out using male Sprague-Dawley rats. Intra-articular injection of 3% formalin was administered to evaluate hyperalgesia 3 days after CFA injection. Intra-articular injection of 3% formalin did not produce nociceptive behavior in normal rats. Although intra-articular injection of 3 doses of CFA produced TMJ inflammation, only 13 diluted CFA produced hyperalgesia when formalin was injected intra-articularly 3 days after CFA injection. Co-administration of IL-1 receptor inhibitor with formalin into the TMJ cavity 3 days after CFA injection was performed. Co-administration of IL-1 receptor inhibitor significantly inhibited formalin-induced hyperalgesia in rats with CFA-induced TMJ inflammation. These results suggested that intra-articular injection of formalin produced hyperalgesia under chronic TMJ inflammation. Moreover, IL-1β plays an important role in TMJ hyperalgesia under chronic inflammation and blockade of IL-1β is a potential therapeutic target for inflammatory TMJ pain.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Articulación Temporomandibular
/
Interleucina-1
/
Ratas Sprague-Dawley
/
Modelos Animales
/
Nocicepción
/
Formaldehído
/
Hiperalgesia
/
Inflamación
/
Inyecciones Intraarticulares
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
International Journal of Oral Biology
Año:
2016
Tipo del documento:
Artículo
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