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Effect of β-carotene on Cell Growth Inhibition of KB Human Oral Cancer Cells
International Journal of Oral Biology ; : 105-111, 2016.
Artículo en Inglés | WPRIM | ID: wpr-124493
ABSTRACT
β-carotene is present in carrots, pumpkins, and sweet potatoes. It suppresses many types of cancers by regulating cellular proliferation and apoptosis through a variety of mechanisms. However, the effects of β -carotene on oral cancer cells have not been clearly established. The main goal of this study was to investigate the effects of β-carotene on cell growth and apoptosis in oral cancer cells. Our results demonstrate that treatment with β-carotene induced inhibition of cell growth, and that the effect was dependent on β-carotene treatment time and concentration in KB cells. Furthermore, treatment with β-carotene induced nuclear condensation and fragmentation in KB cells. β-carotene promoted proteolytic cleavage of procaspase-3, -7, -8 and -9 with associated increases in the concentration of cleaved caspase-3, -7, -8 and -9. In addition, the level of cleaved PARP was increased by β-carotene treatment in KB cells. These results suggest that β-carotene can suppress cell growth and induce apoptosis in KB human oral cancer cells, and that it may have potential usefulness in anti-cancer drug discovery efforts.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Boca / Células KB / Muerte Celular / Apoptosis / Daucus carota / Ipomoea batatas / Cucurbita / Proliferación Celular / Caspasa 3 / Descubrimiento de Drogas Límite: Humanos Idioma: Inglés Revista: International Journal of Oral Biology Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Boca / Células KB / Muerte Celular / Apoptosis / Daucus carota / Ipomoea batatas / Cucurbita / Proliferación Celular / Caspasa 3 / Descubrimiento de Drogas Límite: Humanos Idioma: Inglés Revista: International Journal of Oral Biology Año: 2016 Tipo del documento: Artículo