A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis
Experimental & Molecular Medicine
;
: e31-2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-124615
ABSTRACT
Long intergenic non-coding RNAs (lincRNAs) have historically been ignored in cancer biology. However, thousands of lincRNAs have been identified in mammals using recently developed genomic tools, including microarray and high-throughput RNA sequencing (RNA-seq). Several of the lincRNAs identified have been well characterized for their functions in carcinogenesis. Here we performed RNA-seq experiments comparing gastric cancer with normal tissues to find differentially expressed transcripts in intergenic regions. By analyzing our own RNA-seq and public microarray data, we identified 31 transcripts, including a known expressed sequence tag, BM742401. BM742401 was downregulated in cancer, and its downregulation was associated with poor survival in gastric cancer patients. Ectopic overexpression of BM742401 inhibited metastasis-related phenotypes and decreased the concentration of extracellular MMP9. These results suggest that BM742401 is a potential lincRNA marker and therapeutic target.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Neoplasias Gástricas
/
ARN Mensajero
/
Regulación Neoplásica de la Expresión Génica
/
Modelos de Riesgos Proporcionales
/
Análisis de Supervivencia
/
Análisis Multivariante
/
Reproducibilidad de los Resultados
/
Predisposición Genética a la Enfermedad
/
Etiquetas de Secuencia Expresada
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS