Altered Expression of Nephrin, Glomerular Epithelial Cell Protein-1 (GLEPP1) and WT-1 in Glomerular Disease
Korean Journal of Pathology
;
: 21-29, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-124715
ABSTRACT
BACKGROUND:
Glomerular epithelial cell protein-1 (GLEPP1) and WT-1 expressed in mature visceral glomerular epithelial cell (VGEC) is required for maintenance of the mature status of VGEC. Nephrin protein is located at the filtration slit and regarded as a molecular component of the slit diaphragm. Alterations of these proteins in proteinuric diseases are not clearly defined.METHODS:
We investigated the expression of GLEPP1, WT-1 and nephrin in 28 renal biopsies diagnosed with minimal change nephropathy (n=10), focal glomerulosclerosis (n=10) and membranous nephritis (n=8) by immunohistochemical staining. Normal control biopsies were obtained from six nephrectomy specimens.RESULTS:
The patients consisted of 15 males and 13 females. The mean age was 40.7 years. Nephrotic range proteinuria (> or =3.5 g/day) was noted in 15 (54%) patients. GLEPP1 and nephrin expression were significantly decreased in patients as compared with those of the controls (p<0.05). The mean number of WT-1 expressing cells per glomerulus was also significantly decreased in patients as compared with those of the controls (p<0.05). However, there was no significant difference in the number of WT-1 expressing cells among the disease groups.CONCLUSIONS:
These results suggest that the loss of biological markers of mature VGEC may play an important role in the pathogenesis of proteinuria.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteinuria
/
Biopsia
/
Diafragma
/
Glomeruloesclerosis Focal y Segmentaria
/
Biomarcadores
/
Células Epiteliales
/
Filtración
/
Nefrectomía
/
Nefritis
/
Nefrosis Lipoidea
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Pathology
Año:
2002
Tipo del documento:
Artículo
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