A Cost-Benefit Analysis of Neonatal Screening Tests for Maple Syrup Urine Disease, Homocystinuria, Galactosemia, and Congenital Adrenal Hyperplasia
Journal of Genetic Medicine
;
: 111-118, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-124733
ABSTRACT
PURPOSE:
Neonatal screening tests are increasingly being used forearly diagnosis of inborn errors of metabolism (IEM) in the hope of avoiding the severe developmental delay, acute illness, and death that may result from these diseases. In this study, a cost-benefit analysis was performed on the neonatal screening of maple syrup urine disease, homocystinuria, galactosemia, and congenital adrenal hyperplasia in Korea. MATERIALS ANDMETHODS:
This study included 1,259,220 Korean newborns born between January 2005 to December 2007, who were screened for maple syrup urine disease, homocystinuria, galactosemia, and congenital adrenal hyperplasia. We calculated and compared the total costs in cases where these four screening tests were implemented, and those where they were not.RESULTS:
There were no benefits to screening for maple syrup urine disease or homocystinuria due to their low prevalence for these two tests, the costs exceeded the benefits at benefitcost ratios of 0.51 and 0.61, respectively. In contrast, benefits far exceed costs at a ratio of 4.11 for galactosemia and 2.91 for congenital adrenal hyperplasia. The average benefitcost ratio for all four tests was 2.01.CONCLUSION:
Neonatal screening tests for maple syrup urine disease, homocystinuria, galactosemia, and congenital adrenal hyperplasia are financially viable.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamizaje Masivo
/
Prevalencia
/
Tamizaje Neonatal
/
Análisis Costo-Beneficio
/
Hiperplasia Suprarrenal Congénita
/
Acer
/
Galactosemias
/
Homocistinuria
/
Corea (Geográfico)
/
Enfermedad de la Orina de Jarabe de Arce
Tipo de estudio:
Estudio diagnóstico
/
Evaluación Económica en Salud
/
Estudio de prevalencia
/
Estudio de tamizaje
Límite:
Humanos
/
Recién Nacido
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Journal of Genetic Medicine
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS