Two Cases of Anti-Glomerular Basement Membrane Antibody Disease Associated with Perinuclear-Anti-Neutrophil Cytoplasmic Antibody / 대한내과학회지
Korean Journal of Medicine
;
: 514-519, 2012.
Artículo
en Coreano
| WPRIM
| ID: wpr-12477
ABSTRACT
Anti-glomerular basement membrane antibody (anti-GBM Ab) disease is characterized by circulating antibodies to the glomerular basement membrane and the deposition of IgG or, rarely, IgA along the glomerular basement membrane. This disease accounts for 10-20% of crescentic glomerulonephritis. We report two patients with anti-GBM Ab disease who were positive for perinuclear-anti-neutrophil cytoplasmic antibody (p-ANCA). Percutaneous renal biopsies showed many crescent formations and linear deposits of IgG along the glomerular basement membrane. Serologic tests for p-ANCA were positive. They were treated with steroid pulse and cyclophosphamide and one patient also underwent plasma exchange therapy. Despite immunosuppressive therapy, their renal functions did not improve and both required regular hemodialysis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Intercambio Plasmático
/
Autoanticuerpos
/
Membrana Basal
/
Biopsia
/
Inmunoglobulina A
/
Inmunoglobulina G
/
Pruebas Serológicas
/
Diálisis Renal
/
Anticuerpos Anticitoplasma de Neutrófilos
/
Ciclofosfamida
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2012
Tipo del documento:
Artículo
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